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KMID : 1007520180270061833
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Food Science and Biotechnology
2018 Volume.27 No. 6 p.1833 ~ p.1842
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Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome
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Jo Kyung-Ae
Kim Hoon
Choi Hyeon-Son
Lee Seung-Su
Bang Myun-Ho
Suh Hyung-Joo
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Abstract
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The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.
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KEYWORD
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Glyceryl monolinoleate, Polygonatum sibiricum, Insomnia, Sleep, GABA type A-benzodiazepine receptor
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